biochimica clinica

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CONTRIBUTI SCIENTIFICI – Scientific Papers

Volume:

Biochimica Clinica 2018; 42(1) 26-31

Pubblicato on-line:

Gennaio 30, 2018

DOI:

10.19186/BC_2018.008

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Autenticazione richiesta

1H NMR-based metabolomics study on follicular fluid from patients with Polycystic Ovary Syndrome

AUTORI

Nunzia Iaccarino1, Jussara Amato1, Bruno Pagano1, Alessia Pagano1, Laura D’Oriano2, Sveva Pelliccia1, Mariateresa Giustiniano1, Diego Brancaccio1, Francesco Merlino1, Ettore Novellino1, Carlo Alviggi2, Antonio Randazzo1
1Department of Pharmacy, University of Naples Federico II, Naples, Italy
2Department of Neuroscience, Reproductive Medicine, Odontostomatology, University of Naples Federico II, Naples, Italy

ABSTRACT

Among reproductive-age women, polycystic ovary syndrome (PCOS) is a common endocrine disorder often associated with infertility and insulin resistance. Metabolomics studies on follicular fluid (FF) have shown to provide information about changes in the physiological state of patients as well as biomarkers for oocyte quality. In this context, we performed an exploratory NMR-based metabolomic study on FF samples provided from PCOS women that were undergoing an in vitro fertilization (IVF) therapy. We found that the hyperinsulinemia in PCOS patients is responsible for a different FF metabolic profile. In particular, hyperinsulinemia seems to be associated with impaired carbohydrate/glucose metabolism. Interestingly, plasma concentrations of Anti-Müllerian hormone (AMH) turned out to be positively correlated with glucose and negatively correlated with lactate, pyruvate and alanine. To the best of our knowledge, this is the first study that attempts to correlate AMH values with the FF metabolites. Although the data reported here are preliminary, this study paves the way to a better comprehension of the relationships among hormones and metabolites in FF.

BIBLIOGRAFIA