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Italian EDITORIALI - Editorials
Volume:
Published on-line:
March 1, 2020
DOI:
10.19186/BC_2020.020
Applicazioni cliniche della presepsina come biomarcatore diagnostico d’infezione: rassegna e aggiornamenti
Clinical application of presepsin as diagnostic biomarker of infection: overview and updates
AUTHORS
1PhD, Department of Biomedical Sciences for Health, Università degli Studi di Milano, Italy; and IRCCS Orthopedic Institute Galeazzi, Milan, Italy
2Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy
3IRCCS Orthopedic Institute Galeazzi, Milan, Italy
4Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy; and U.O.C. SMEL-1 Patologia Clinica IRCCS Policlinico San Donato, San Donato, Milan, Italy
ABSTRACT
Clinical application of presepsin as diagnostic biomarker of infection: overview and updates
The appropriate identification of bacterial infection is the basis for effective treatment and control of infective disease. Among this context, an emerging biomarker of infection is presepsin (PSP), re-cently described as early marker of different infections. PSP secretion has been shown to be associ-ated with monocyte phagocytosis and plasmatic levels of PSP increase in response to bacterial infec-tion and decrease after antibiotic treatment, therefore it can be considered a marker of activation of immune cell response towards an invading pathogen. Different methods have been developed to measure PSP and this review will briefly describe the different clinical fields of application of PSP, ranging from intensive care to neonatal infection, to orthopedic and pulmonary infection as well as fungal infections and cardiovascular infections.