English 
Italian CONTRIBUTI SCIENTIFICI – Scientific Papers
Volume:
Biochimica Clinica 2019; 43(4) 399-405
Pubblicato on-line:
July 4, 2019
DOI:
10.19186/BC_2019.040
Comparative study of galectin-3, brain natriuretic peptide, cystantine C and high sensitivity troponin determinations in the diagnosis of heart failure in elderly italian males
AUTORI
1Servizio di Medicina di Laboratorio, Ospedale Madonna della Navicella, Chioggia
2Servizio di Medicina Trasfusionale, Ospedale dell’Angelo, Mestre
3Cardiologia ed Unità Coronarica, Ospedale Madonna della Navicella, Chioggia
4Unità Operativa Complessa di Cardiologia Universitaria, Azienda Ospedaliera Universitaria, Policlinico Consorziale di Bari
5Scuola di Igiene e Sanità Pubblica Università di Padova.
ABSTRACT
Introduction: heart failure (HF) has been defined a modern pandemic. The complex array of physiologic, psychological, social and health care issues makes it a challenging chronic disease to diagnose and manage. Our study is aimed to evaluate a multi-markers approach in diagnosis of HF in aged males.
Methods: 68 Italian males aged >65 years have been enrolled; 25 were patients with heart failure (HF) and 43 were healthy controls. In all the subjects, measurements of high sensitivity troponin I (TNI), galectin-3 (GAL), cystatin C (CYS) and brain natriuretic peptide (BNP) were performed using routine methods.
Results: in patients with HF, mean concentrations of TNI, GAL, CYS and BNP were significantly higher (p<0.001) than values observed in controls subjects. Only BNP and GAL showed a correlation with NHYA stage of HF. In this study, GAL and BNP demonstrated better diagnostic perfomamces to differentiate of HF patients from controls subjects.
Conclusions: our study showed the usefulness of a strategy involving multiple biomarkers determination in laboratory diagnosis of HF in elderly males.