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Volume:
Biochimica Clinica 2022; 46(1) 078-082
Pubblicato on-line:
January 1, 2021
DOI:
10.19186/BC_2021.071
Determinazione e utilizzo clinico di autoanticorpi e/o di profili autoanticorpali nelle malattie epatiche autoimmuni – aggiornamento 2021
Description and clinical use of autoantibody determination in autoimmune liver diseases – update 2021
AUTORI
1SSUO Diagnostica delle Malattie Autoimmuni - UOC Diagnostica Ematochimica; Azienda Ospedaliero Universitaria, Parma
2SSUO Diagnostica delle Patologie Autoimmuni - Dipartimento Integrato Aziendale di Medicina di Laboratorio e Anatomia Patologica Azienda Ospedaliera Universitaria e Azienda USL di Modena, Nuovo Ospedale S. Agostino Estense
3Dipartimento Integrato Aziendale di Medicina di Laboratorio e Anatomia Patologica Azienda Ospedaliera Universitaria
e Azienda USL di Modena, Nuovo Ospedale S. Agostino Estense
ABSTRACT
Description and clinical use of autoantibody determination in autoimmune liver diseases – update 2021, on behalf of the Study Group “Autoimmune Diseases” of the Italian Society of Clinical Biochemistry
Description and clinical use of autoantibody determination in autoimmune liver diseases – update 2021, on behalf of the Study Group “Autoimmune Diseases” of the Italian Society of Clinical Biochemistry. The autoantibody assessment in the field of autoimmune liver disease is crucial both for diagnosis and prognosis. Although these autoantibodies are sometime present even in the normal healthy individuals, their presence is a prerequisite to diagnose autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC); some of these autoantibodies are included in the diagnostic scoring system for these diseases. The laboratory diagnostics of autoimmune liver diseases, traditionally carried out using indirect immunofluorescence testing (IFT) on rodent tissue slices, has achieved substantial improvements due to innovative analytical opportunities, such as ELISA-based diagnostic assay and Multiple Immunodot Liver profile test based on recombinant or purified antigens. The aim of this document is to highlight the crucial role of the new antigen specific tests for a better diagnostic strategy in the field of the three major autoimmune liver diseases AIH, PBC and Primary sclerosing cholangitis (PSC).