Gammopatie monoclonali di significato clinico

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ABSTRACT

Monoclonal gammopathies of clinical significance.

This Opinion is aimed to comment and emphazise the main points raised in a seminal paper published in 2018 in Blood. The paper deals with a number of severe diseases caused by small lymphoid/plasma cell clones. These clones affect different organs by means of the biological properties of the clonal cells themselves and/or of their secretion products such as monoclonal immunoglobulins, cytokines and other molecules. More importantly, the paper also deals with the pathogenetic mechanisms involved in the organ damage and sheds light on most of them. The present comment aims to bring attention to these diseases, but it does not encompass the whole matter. We suggest that the readers involved in this matter refer to the paper in its original version.

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