English 
Italian DOCUMENTI SIBIOC - SIBioC Documents
Volume:
Biochimica Clinica 2014; 38(1) 47-53
Published on-line:
DOI:
Il contributo della diagnostica proteica nella gestione delle gammopatie monoclonali
AUTHORS
1Laboratorio Generale, Dipartimento Aziendale Integrato di Diagnostica Laboratorio, Azienda Ospedaliero-Universitaria Careggi, Firenze
2Azienda Ospedaliera Universitaria Integrata di Verona
3Laboratorio di Immunologia, Dipartimento di Medicina di Laboratorio, Facoltà di Medicina, Università Cattolica del Sacro Cuore, Policlinico “A. Gemelli”, Roma
4Laboratorio di Patologia Clinica, Ospedale Clinicizzato SS Annunziata, Chieti
5Patologia Clinica, Dipartimento di Prevenzione e Diagnostica Oncologica, Istituto Nazionale Tumori Regina Elena, IRCCS, Roma
6Laboratoro di Analisi, Ospedale Belcolle, Azienda Unità Sanitaria Locale, Viterbo
7Laboratorio Centrale, IRCCS Azienda Ospedaliera Universitaria San Martino-IST, Genova
8Centro di Medicina di Laboratorio e Anatomia Patologica MultiLab, IRCCS MultiMedica, Milano
9Centro per lo Studio e la Cura delle Amiloidosi Sistemiche, Laboratorio di Biotecnologie e Tecnologie Biomediche, Fondazione IRCCS Policlinico S. Matteo, Pavia
ABSTRACT
Protein diagnostics in the management of monoclonal gammopathies
This document examines laboratory tests to be used for the management of monoclonal gammopathies in different clinical scenarios, from screening to monitoring and assessment of the response to therapy. The content is based on international recommendations and guidelines currently available. It includes sections on the analytical aspects of different tests (serum protein electrophoresis, typing and quantification of monoclonal components, Bence Jones protein determination and free light chain measurement) and on their clinical significance as well. Different clinical settings are examined: screening, diagnosis, risk stratification, monitoring and response assessment. For each of those, laboratory tests to be used are indicated. Aim of the document is to help clinical laboratories avoiding unnecessary tests, ensuring in the meantime that all the investigations required for a optimal patient management are carried out.