English 
Italian CASI CLINICI – Case Reports
Volume:
Biochimica Clinica 2014; 38(6) 639-650
Published on-line:
DOI:
Microbioma intestinale umano e metabolismo corporeo: implicazioni per obesità e diabete
AUTHORS
Department of Pathology and Immunology, Baylor College of Medicine and Department of Pathology, Texas Children's Hospital, Houston, USA
Traduzione a cura di Francesca Avemaria e Andrea Mosca
ABSTRACT
The human gut microbiome and body metabolism: implications for obesity and diabetes
Obesity, metabolic syndrome and type 2 diabetes are major public health challenges. Recently, interest has surged regarding the possible role of the intestinal microbiota as potential novel contributors to the increased prevalence of these three disorders. Recent advances in microbial DNA sequencing technologies have resulted in the widespread application of whole-genome sequencing technologies for metagenomic DNA analysis of complex ecosystems such as the human gut. Current evidence suggests that the gut microbiota affect nutrient acquisition, energy harvest and a myriad of host metabolic pathways. Advances in the Human Microbiome Project and human metagenomics research will lead the way toward a greater understanding of the importance and role of the gut microbiome in metabolic disorders such as obesity, metabolic syndrome and diabetes.