English 
Italian CASI CLINICI – Case Reports
Volume:
Biochimica Clinica 2019; 43(2) e20-e23
Pubblicato on-line:
April 16, 2019
DOI:
10.19186/BC_2019.030
Paziente pediatrico con oliguria e adenopatia cervicale: il ruolo degli analizzatori a cattura di immagine per l’esame standard delle urine
AUTORI
1Laboratorio di Patologia Clinica Core-Lab Ospedale Civile S. Agostino Estense. Modena
2Laboratorio di Citopatologia, Ospedale di Mirandola.
3Laboratorio di Virologia, AOU Policlinico. Modena
ABSTRACT
Urinalysis in a pediatric patient with oliguria and cervical lymphadenopathy: role of automated imageanalysis systems.
Automated urinalysis instruments image-based for cell analysis can identify non-squamousepithelial cells (NSE). Among these elements, expert pathologists can distinguish the so called Decoy Cells (DC),Polyomavirus BK (BKV)-infected elements primarily seen in immunocompromised patients. Epstein-Barr virus (EBV)infection can induce a transient immunosuppression in immunocompetent patients, and this could lead to areactivation of a latent BKV infection in urothelial cells: this is a rare event in pediatric patients. This study reports thecase of a 4 year-old child with lateral lymphadenopathy, fever and oliguria. Automated urinary sediment analysisevidenced the presence of many NSEs identifed as DC, generating a subsequent virological investigation with a finaldiagnosis of concomitant BKV and EBV infection. The combination of an automated technology, an efficientmiddleware and the expertise of the laboratory professionals , allowed the proper identification of these peculiarreactive elements, which could easily be mistaken for malignant atypical cells.