English 
Italian RASSEGNE - Reviews
Volume:
Biochimica Clinica 2014; 38(3) 198-202
Pubblicato on-line:
DOI:
Scarica in PDF:
Autenticazione richiesta
Proteomica e metabolomica nello studio della malattia di Alzheimer
AUTORI
Francesca Sicilia, Giulia Maria Sancesario, Giorgio Federici
Dipartimento di Medicina di Laboratorio, Fondazione Policlinico Tor Vergata, e Dipartimento di Medicina Sperimentale e Chirurgia, Università di Roma Tor Vergata, Roma
Dipartimento di Medicina di Laboratorio, Fondazione Policlinico Tor Vergata, e Dipartimento di Medicina Sperimentale e Chirurgia, Università di Roma Tor Vergata, Roma
ABSTRACT
Proteomic and metabolomic approaches in the study of Alzheimer disease (AD)
Pathophysiologic changes associated with AD begin decades before the appearance of clinical symptoms; it is therefore essential an advancement of the knownledge of the etiopathogenetic process in early stages of disease. Proteomics and metabolomics are powerfull tools for the study and the comprehensive analysis of proteins and low MW compounds in a biological sample. These tools show great potential for the discovery of new biomarkers. Here we analyze recent developments in the application of proteomic and metabolomic technologies for searching new biomarkers for AD.