English 
Italian CASI CLINICI – Case Reports
Volume:
Biochimica Clinica 2019; 43(4) e38-e40
Published on-line:
October 15, 2019
DOI:
10.19186/BC_2019.062
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Un caso clinico di linfocitosi persistente
AUTHORS
Blerina Jance1, Benedetta Salvadori1, Francesca Cesari1, Angela Rogolino1, Benedetta Peruzzi2, Roberto Caporale2, Alessandra Fanelli1
1Laboratorio Generale, Azienda Ospedaliero-Universitaria Careggi, Firenze
2Centro diagnostico di Citometria e Immunoterapia, Azienda Ospedaliero-Universitaria Careggi, Firenze
1Laboratorio Generale, Azienda Ospedaliero-Universitaria Careggi, Firenze
2Centro diagnostico di Citometria e Immunoterapia, Azienda Ospedaliero-Universitaria Careggi, Firenze
ABSTRACT
Persistent Lymphocytosis
Persistent Polyclonal Binucleated B-cell Lymphocytosis (PPBL) is a rare, benign hematological disorder characterized by a chronic polyclonal B-cell lymphocytosis with binucleated lymphocytes. We report the clinical case of a young woman with lymphocytosis who presented binucleate lymphocytes at the morphological examination of the peripheral venous blood smear. Flow cytometry immunophenotyping performed in peripheral blood showed a polyclonal lymphocyte B subpopulation. Serological tests were negative for viral infections. Because of its benign and indolent course, the diagnoses of PPBL is important in order to avoid unnecessary diagnostic procedures and therapies.