Italian 
English Falsely elevated Digoxin levels detected in patient on concomitant use of Enzalutamide
AUTORI
Stefano De Angelis1, Ernesto Trabuio1, Elisa Zonta2, Antonio Antico1
1U.O.C. Laboratorio Analisi, ULSS7 Pedemontana, Bassano del Grappa (Vicenza)
2 Direzione Medica Ospedaliera, ULSS7 Pedemontana, Bassano del Grappa (Vicenza)
1U.O.C. Laboratorio Analisi, ULSS7 Pedemontana, Bassano del Grappa (Vicenza)
2 Direzione Medica Ospedaliera, ULSS7 Pedemontana, Bassano del Grappa (Vicenza)
ABSTRACT
Enzalutamide may cause falsely elevated Digoxin levels using chemiluminescent microparticle immunoassay analytical method.
This report describes the case of an 81 year old man treated with Enzalutamide since 2019 and Digoxin for the last 15 days before emergency ward admission with falsely elevated Digoxin levels.
The study reveals an analytical interference with the chemiluminescent immunoassay utilized concerning falsely elevated Digoxin levels with concomitant use of Enzalutamide.
In agreement with similar reports in the literature, patients on Enzalutamide, should have the Digoxin levels measured with alternative methods.