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Volume:
Biochimica Clinica 2019; 43(3) 313-326
Pubblicato on-line:
Aprile 29, 2019
DOI:
10.19186/BC_2019.024
La variabilità preanalitica in coagulazione
AUTORI
1 Laboratorio Analisi Synlab Castenedolo, Brescia
2 Laboratorio Analisi Chimico Cliniche e Microbiologiche, Azienda Ospedaliera Ordine Mauriziano, Torino
3 Laboratorio Analisi, Ospedale San Giovanni Bosco, Azienda Sanitaria Locale Città di Torino
4 Laboratorio di Biochimica Clinica, Azienda Ospedaliero-Universitaria Maggiore della Carità, Novara
5 Laboratorio Analisi, Azienda Ospedaliera Santa Croce e Carle, Cuneo
6 Laboratorio Analisi Chimico Cliniche e Microbiologiche, ASLCN2 Alba-Bra
7 Laboratorio Studio Malattie Emorragiche e Trombotiche, AO SS. Antonio e Biagio, Alessandria
8 Struttura Complessa Laboratorio Analisi, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Presidio Ospedaliero Molinette, Torino
9 Immunoematologia e Centro Trasfusionale ASST Ovest Milanese, Legnano, Milano
10Servizio di Medicina Trasfusionale, Azienda Sanitaria Universitaria Integrata, Trieste
11Struttura Complessa Laboratorio Analisi, Ospedale di Ivrea - ASLTO4, Ivrea
ABSTRACT
Pre-analytical issues in coagulation testing
Poor standardization of preanalytic variables influences greatly thereliability of coagulation testing, consuming health care resources and compromising patient outcomes. Thesevariables include patient preparation, sample collection, handling, transportation, processing, and storage until timeof analysis: lack of standardized procedures for sample collection accounts for most of the errors encountered withinthe total testing process. Most pre-analytical problems may arise from system faults and insufficient audit of theoperators involved in specimen collection and handling, leading to unsuitable specimens due to misidentification,hemolysis, clotting, inappropriate volume, wrong container, contamination from the infusive route. Detection,acknowledgement and management of pre-analytical variables, is mandatory for delivering accurate laboratoryresults. The present document, issued by the Study Group on Haemostasis of the Italian Society of LaboratoryMedicine, is a summary of the recommendations for standardisation of the pre-analytical phase of the coagulationtesting, related to sample collection, transportation, and storage and provides guidance to reduce the effects of pre-analytical issues that can have a significant impact on patient care.