Meccanismi epigenetici nella patogenesi dell’allergia al latte vaccino

AUTORI

ABSTRACT

Epigenetics and cow’s milk allergy: implication for pathogenesis

Cows’ milk allergy (CMA) is one of the most frequent allergies in child, often occurring quite soon after birth. Recent years have been featured by an increasing prevalence of CMA that can often be the first appearance of the so-called “atopic march”. Typically, CMA is featured by immunoglobulin E (IgE)-mediated reactions; however, the pathogenetic basis of IgE-mediated CMA is not yet completely understood. Recent evidences suggest that epigenetic factors, such as DNA methylation and regulatory non-coding RNAs could play a role in allergic diseases, including CMA. Here, we review the state of the art regarding the involvement of some epigenetic modifications in allergic diseases, and especially in CMA. We describe that epigenetic derived molecules, in addition to be pathogenetic factors contributing to typical CMA allergic phenomena, could also serve to produce molecules which may act as novel, specific and easily accessible biomarkers for CMA diagnosis and monitoring.

BIBLIOGRAFIA