biochimica clinica

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CASI CLINICI – Case Reports

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Biochimica Clinica 2016; 40(1) e1-e3

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Sindrome POEMS: “Hevylite” e “Freelite” a confronto

AUTORI

Mara Seguso1, Kozeta Proko1, Daniela Ciubotaru1, Sara Altinier1, Mariacristina Varagnolo1, Martina Zaninotto1, F. Adami2, Mario Plebani1
1Dipartimento di Medicina di Laboratorio, Azienda Ospedaliera - Università di Padova
2Dipartimento di Medicina, Unità di Ematologia, Università di Padova

ABSTRACT

POEMS syndrome: Heavy Light Chains vs Free Light Chains measurements

POEMS syndrome is a rare paraneoplastic, multisystemic, plasma cell discrasia characterized by Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy and Skin changes. Most patients have high serum free light chains (sFLC) concentrations but a normal sFLC ratio. Hevylite (HLC) is a new method that allows separated quantification of the serum k and l bounded levels of the six isotype specific immunoglobulins. In this study HLC and sFLC were measured in serum samples during the follow up of two patients with POEMS syndrome. The HLC ratio of the involved monoclonal immunoglobulin could provide additional information to assess residual disease, allowing detection of relapse earlier than clinical symptoms in patients with POEMS syndrome.

BIBLIOGRAFIA