Trovato l’ago nel pagliaio: il primo caso di Breast Implant-Associated Anaplastic Large Cell Lymphoma (bia-alcl) nell’Azienda Ospedale Università di Padova
Found the needle in a haystack: the first case of Breast Implant-Associated Anaplastic Large Cell Lymphoma (Bia-Alcl) in University-Hospital of Padova

AUTORI

Veronica Davanzo¹, Paola Fogar², Jenny Zuin², Michela Pelloso², Kathrin Ludwig³, Marco Pizzi³, Luisa Santoro³, Marcello Lo Mele³, Maria Cristina Toffanin⁴, Daniela Basso^1,2
¹Università degli Studi di Padova, UOC Medicina di Laboratorio, DIDAS Servizi di Diagnostica Integrata
²Azienda Ospedale Università di Padova, UOC Medicina di Laboratorio, DIDAS Servizi di Diagnostica Integrata
³Azienda Ospedale Università di Padova, UOC Anatomia e Istologia Patologica, Dipartimento di Medicina DIMED
⁴Istituto Oncologico Veneto IOV IRCCS, Dipartimento di Chirurgia Senologica

Questo contributo è stato in parte presentato al 54° Congresso nazionale SIBioC di Genova, 4-7 ottobre 2022, nella sessione Casi Clinici

ABSTRACT

Found the needle in a haystack: the first case of Breast Implant-Associated Anaplastic Large Cell Lymphoma (Bia-Alcl) in University-Hospital of Padova

A 51-year-old woman complained of a periprosthetic effusion ten years after a breast prosthesis implantation. The effusion was aspirated and the seroma was sent for flow cytometry and immunohistochemical analysis to the laboratories of the University-Hospital of Padova. The analyses revealed the presence of a lymphoid population with an abnormal phenotype and morphology. All neoplastic cells were large cells with anaplastic morphology, they were CD30-positive and Anaplastic Lymphoma Kinase (ALK)-negative. By integrating the clinical-anamnestic data with laboratory data, a diagnosis of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) was made. This is a rare type of non-Hodgkin lymphoma that affects women with breast implants. Since this lymphoma was recognized by the WHO in 2016, only a few cases of BIA-ALCL have been described. However, thanks to the diagnostic workup introduced by the National Comprehensive Cancer Network guidelines and applied by the University-Hospital of Padova, the diagnosis of a still little-known and extremely rare lymphoma was possible.

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