Italian 
English CASI CLINICI – Case Reports
Volume:
Biochimica Clinica 2020; 44(2) E08-E10
Pubblicato on-line:
Gennaio 15, 2020
DOI:
10.19186/BC_2020.002
Un caso di gammopatia monoclonale di significato renale
A case of monoclonal gammopathy of renal significance
AUTORI
1Centro per lo Studio e la Cura delle Amiloidosi Sistemiche, Laboratorio Biochimica - Biotecnologie e Diagnostica avanzata, Fondazione IRCCS Policlinico San Matteo, Dipartimento di Medicina Molecolare, Università di Pavia, Pavia
2Servizio di Analisi Chimico Cliniche, Fondazione IRCCS Policlinico San Matteo, Pavia
ABSTRACT
A case of monoclonal gammopathy of renal significance.
Monoclonal gammopathy of renal significance (MGRS) is a condition defined by the presence of a small-B cell clone causing a renal disease trough deposition in renal tissues of the monoclonal component (MC) secreted by the B cells. Since MGRS is associated with several types of renal diseases, characterization of renal damage caused by protein deposition is important to define the correct diagnosis as well as the identification of the MC. Adult Fanconi Syndrome (FS) is characterized by the presence of a MC and damage in the proximal tubule with impaired small molecules transport. We report the case of a 32 years old man with moderate kidney failure, normoglycemic glycosuria and hypouricemia. Further investigations revealed hypophosphoremia and phosphaturia; an IgGκ MC was detected by immunofixation. The kidney biopsy confirmed FS suspect. This case underlines that the results of the biochemical analysis carried on for the diagnosis of FS, need to be confirmed by histopathologic analysis.