Italian 
English CASI CLINICI – Case Reports
Volume:
Biochimica Clinica 2019; 43(3) e28-e30
Pubblicato on-line:
Luglio 4, 2019
DOI:
10.19186/BC_2019.055
Una malattia neurologica di difficile inquadramento
AUTORI
Dipartimento Interaziendale di Medicina di Laboratorio ed Anatomia Patologica ad Attività Integrata,
Ospedale Civile S. Agostino Estense, AUSL, Modena
ABSTRACT
A neurological disease difficult to classify
We describe a case of a 32 year old woman visiting to the NeurologyUnit with progressive bi-frontal headache and reduced visual acuity followed by disequilibrium and dysarthria.
Cerebrospinal fluid (CSF) analysis documented pleyocitosis with slight CSF-blood-barrier damage.
Routine laboratory tests that were all negative except for the presence of serum anti-myelin oligodendrocyteglycoprotein (MOG) antibody.
Thanks to the laboratory test results, neurologists could classified the patient as a case of encephalomyelitis anti-MOG antibody related and have treated her with methylprednisolone followed by Rituximab with clinical improvementand reduction of brain lesion.
Anti-MOG antibody associated to encephalomyelitis is currently considerated as a distinct nosologic entityimmunopathogenetically identifiable among the neuromyelitis spectrum disorders.
The case illustrated here underlines the central role of the clinical laboratory for the correct diagnosis of demyelinatingnervous system diseases.