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DOCUMENTI - Documents

Volume:

Biochimica Clinica, aop

Pubblicato on-line:

Novembre 15, 2024

DOI:

10.19186/BC_2063.067

Scarica in PDF:
Autenticazione richiesta

Young Scientists: il motore della Medicina di Laboratorio

AUTORI

Andrea Bartolini1, Daria Debbia2, Ilenia Aversa3, Ilaria Baudone4, Laura Bergantini5, Margherita Borriello6, Alessia Cafaro7, Chiara Della Franca8, Alice Nevone9, Eleonora Sabetta10, Margherita Scapaticci11, Rossella Tomaiuolo11,12, Tommaso Trenti2, Giulia Sancesario13

ABSTRACT

Young Scientists: the engine of Laboratory Medicine

The acquisition of solid skills for planning of careers has always represented a challenge for a Young Scientist (YS). The current desire for a restart after the recent pandemic, places even more attention on these issues, offering young specialists in Clinical Biochemistry and Laboratory Medicine the possibility of being the driving force behind this restart. To do this, it is essential to invest in own skills, develop an accurate strategy, be a change maker and, sometimes, think outside the box. This paper collects some important themes discussed during the conference “Young Scientists: the engine of Laboratory Medicine” organized by the SIBioC YS Study Group, which took place in Modena (Italy) in December 2023.

BIBLIOGRAFIA

  1. Sciacovelli L, Santini SA, Plebani M. Developing and enhancing all the professional activities for a successful future of Laboratory Medicine. Biochim Clin 2023;47 Suppl2:S69-73.
  2. Bellini C, Nannini S, Berardi M, Mosca A, Bernardini S, Sancesario G. Il “Libro Bianco” dei Giovani Professionisti di Medicina di Laboratorio in Italia: risultati dell’indagine del Gruppo di Studio SIBioC Young Scientists. Biochim Clin 2020; 44:351-8.
  3. Ammirabile M, Aita A, Bartolini A, Spolaore F, Scapaticci M, Pellegrini C, et al. Impatto dell’emergenza COVID-19 nei laboratori: esperienze e opinioni dei SIBioC Young Scientists. Biochim Clin 2020; 44:21-2.
  4. D’Argenio V, Iorio E, Tomaiuolo R, Bellini C, Lenski M, Gianella E, et al. Comunicare nell’infosfera: sfide e opportunità per la Medicina di Laboratorio. Biochim Clin 2021; 45:290-8.
  5. Adler J, Lenski M, Tolios A, Fares Taie S, Sopic M, Rajdl D, et al. Digital competence in laboratory medicine. JLM 47; 2023:143-8.
  6. Rodari G. Il libro degli errori. Torino, Einaudi, 1964.
  7. Trasformare il nostro mondo: l’Agenda 2030 per lo Sviluppo Sostenibile – Dipartimento per la Pubblica Informazione Nazioni Unite – 2015 https://unric.org/it/wp-content/uploads/sites/3/2019/11/Agenda-2030-Onu-italia.pdf (Ultimo accesso: maggio 2024).
  8. Sancesario G, Perrone MA, Pellegrini C, Ialongo C, Aita A, Dabla PK, et al. La medicina di laboratorio: gli specialisti di domani. Biochim Clin 2019; 43:424-34.
  9. Rampoldi E, Patrucco G, Casati M, Morelli B, Carraro P. Implementation and management of the point-of-care testing (PoCT): Essential indications. Biochim Clin 2021; 45:312–26.
  10. Charansonney OL, Al-Dandachi G, Plaisance P, Vicaut E. Evaluation of a new point-of-care diagnostic test measuring inflammation in emergency settings. Sci Rep 2023;13:19551.
  11. Borriello M, Tarabella G, D’Angelo P, Liboà A, Barra M, Vurro D, et al. Lab on a chip device for diagnostic evaluation and management in chronic renal disease: a change promoting approach in the patients’ follow up. Biosensors 2023; 13:373.
  12. Della Ventura B, Banchelli M, Funari R, Illiano A, De Angelis M, Taroni P, et al. Biosensor surface functionalization by a simple photochemical immobilization of antibodies: experimental characterization by mass spectrometry and surface enhanced Raman spectroscopy. Analyst 2019; 144:6871-80.
  13. Cascino P, Nevone A, Piscitelli M, Scopelliti C, Girelli M, Mazzini G, et al. Single-molecule real-time sequencing of the M protein: Toward personalized medicine in monoclonal gammopathies. Am J Hematol 2022; 97: E389-92.
  14. Nevone A, Girelli M, Mangiacavalli S, Paiva B, Milani P, Cascino P, et al. An N-glycosylation hotspot in immunoglobulin κ light chains is associated with AL amyloidosis. Leukemia 2022; 36:2076-85.
  15. Gazzetta Ufficiale. Decreto Ministeriale 9 Novembre 2015. Funzioni di Organismo Statale per la Cannabis Previsto dagli Articoli 23 e 28 della Convenzione Unica Sugli Stupefacenti del 1961, Come Modificata nel 1972. https://www.gazzettaufficiale.it/eli/id/2015/11/30/15A08888/sg;jses (Ultimo accesso: settembre 2024).
  16. MacCallum CA, Russo EB. Practical considerations in medical cannabis administration and dosing. Eur J Intern Med 2018; 49:12–19.
  17. Elsohly MA, Slade D. Chemical constituents of marijuana: The complex mixture of natural cannabinoids. Life Sci 2005; 78:539–48.
  18. Palermiti A, Cafaro A, Barco S, Bucchioni P, Franceschini P, Cusato J, et al. Analysis of cannabinoids concentration in cannabis oil galenic preparations: Harmonization between three laboratories in northern Italy. Pharmaceuticals (Basel). 2021;14:462.
  19. Romano LL, Hazekamp A. Cannabis oil: Chemical evaluation of an upcoming cannabis- based medicine. Cannabinoids 2013; 1:1-11.
  20. Cangemi G, Bucchioni P, Tripodi G, Barco S, Franceschini P, Sbarbaro IM. Analysis of cannabinoids concentration in cannabis oil galenic preparations in the Liguria Region: experimental project of the regional reference laboratories. Biochim Clinic 2020;,44:367-79.
  21. Cafaro A, Conti M, Pigliasco F, Barco S, Bandettini R, Cangemi G. Biological Fluid Microsampling for Therapeutic Drug Monitoring: A Narrative Review. Biomedicines 2023, Vol 11, Page 1962 2023;11:1962. https://doi.org/10.3390/BIOMEDICINES11071962
  22. Babu M, Snyder M. Multi-omics profiling for health. Mol Cell Proteomics 2023;22: 100561.
  23. Feldman EL, Goutman SA, Petri S, Mazzini L, Savelieff MG, Shaw PJ, et al. Amyotrophic lateral sclerosis. Lancet 2022; 400:1363-80.
  24. Balendra R, Isaacs AM. C9orf72-mediated ALS and FTD: multiple pathways to disease. 14, Nature Reviews Neurology.  Nat Rev Neurol 2018; 14:544-58.
  25. Sproviero W, Shatunov A, Stahl D, Shoai M, van Rheenen W, Jones AR, et al. ATXN2 trinucleotide repeat length correlates with risk of ALS.  Neurobiol Aging 2017; 51:178. e1-e9.
  26. Johnsen B. Diagnostic criteria for amyotrophic lateral sclerosis from El Escorial to Gold Coast. Clin Neurophysiol 2020; 131:1962-3.
  27. Thomas Q, Coarelli G, Heinzmann A, Le Ber I, Amador M del M, Durr A. Questioning the causality of HTT CAG-repeat expansions in FTD/ALS.
    Neuron 2021; 109:1945-6.
  28. Jih KY, Lai KL, Lin KP, Liao YC, Lee YC. Reduced-penetrance Huntington’s disease-causing alleles with 39 CAG trinucleotide repeats could be a genetic factor of amyotrophic lateral sclerosis. J Chin Med Assoc 2023; 86:47-51.
  29. Brenner D, Müller K, Gastl R, Gorges M, Otto M, Pinkhardt EH, et al. Analysis of CACNA1A CAG repeat lengths in patients with familial ALS. Neurobiol Aging 2019; 74:235.e5-e8.
  30. Wilson DM, Cookson MR, Van Den Bosch L, Zetterberg H, Holtzman DM, Dewachter I. Hallmarks of neurodegenerative diseases. Cell 2023; 186:693-714.
  31. DeGrace MM, Ghedin E, Frieman MB, Krammer F, Grifoni A, Alisoltani A, et al. Defining the risk of SARS-CoV-2 variants on immune protection. Nature 2022; 605:640-52.
  32. Sahin U, Muik A, Derhovanessian E, Vogler I, Kranz LM, Vormehr M, et al. COVID-19 vaccine BNT162b1 elicits human antibody and T(H)1 T cell responses. Nature 2020;586:594-9.
  33. Sette A, Sidney J, Crotty S. T Cell Responses to SARS-CoV-2. Annu Rev Immunol 2023; 41:343-73.
  34. Keeton R, Tincho MB, Suzuki A, Benede N, Ngomti A, Baguma R, et al. Impact of SARS-CoV-2 exposure history on the T cell and IgG response. Cell Rep Med 2023; 4:100898.
  35. Aversa I, Malanga D, Fiume G, Palmieri C. Molecular T-Cell Repertoire Analysis as Source of Prognostic and Predictive Biomarkers for Checkpoint Blockade Immunotherapy. Int J Mol Sci 2020;21:2378.
  36. Musvosvi M, Huang H, Wang C, Xia Q, Rozot V, Krishnan A, et al. T cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection. Nat Med 2023;29:258-69.
  37. Bergantini L, Pianigiani T, D’Alessandro M, Gangi S, Cekoria B, Bargagli E et al. The effect of anti-IL5 monoclonal antibodies on regulatory and effector T cells in severe eosinophilic asthma. Biomed Pharmacother 2023;166:115385.
  38. Lo Muzio G, Calò O, Cisternino C, Scarano P, Sanna A, De Filippis F, et al. Real life benralizumab effectiveness in patients with severe eosinophilic asthma after a 24-month observation. Eur Resp J 2022;60:2154.
  39. Dagher R, Kumar V, Copenhaver AM, Gallagher S, Ghaedi M, Boyd J et al. Novel mechanisms of action contributing to benralizumab’s potent anti-eosinophilic activity. Eur Resp J 2022; 59:2004306.
  40. Sivori S, Vacca P, Del Zotto G, Munari E, Mingari MC, Moretta L. Human NK cells: surface receptors, inhibitory checkpoints, and translational application. Cell Mol Immunol 2019; 16:430-41.
  41. Bergantini L, D’Alessandro M, Pianigiani T, Cekorja B, Bargagli E, Cameli P. Benralizumab affects NK cell maturation and proliferation in severe asthmatic patients. Clin Immunol 2023; 253:1096680.
  42. Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR, et al. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study. Lancet 2020; 395:200-11.
  43. Cox D. Sepsis – it is all about the platelets. Front Immunol 2023; 14:1210219.
  44. Semeraro N, Ammollo CT, Semeraro F, Colucci M. Sepsis, thrombosis and organ dysfunction. Thromb Res 2012; 129:290-5.
  45. Péju E, Fouqué G, Charpentier J, Vigneron C, Jozwiak M, Cariou A, et al. Clinical significance of thrombocytopenia in patients with septic shock: An observational retrospective study. J Crit Care 2023; 76:154293.
  46. Tzur I, Barchel D, Izhakian S, Swarka M, Garach-Jehoshua O, Krutkina E, et al Platelet distribution width: a novel prognostic marker in an internal medicine ward. J Community Hosp Intern Med Perspect 2019; 9:464-70.
  47. Dixit S, Arora JK, Kumar R, Arora R. Role of Routine Blood Parameters in Predicting Mortality Among Surgical Patients With Sepsis. Cureus 2023;15:e37413.
  48. Giglio RV, Ligi D, Della Franca C, Lo Sasso B, Rivas JZ, Agnello L, et al. Thrombocytopenia and hyperinflammation are induced by extracellular histones circulating in blood. Clin Chem Lab Med 2023;61:e239-43.
  49. Ferraro S, Panteghini M. Il futuro della medicina di laboratorio. Biochim Clin 2016; 40:75-7.
  50. Tomaiuolo R, Banfi G. From volume to value: a watershed moment for the clinical laboratory. Clin Chem Lab Med 2023; 62:593-6.

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