biochimica clinica

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CASI CLINICI – Case Reports

Volume:

Biochimica Clinica 2022; 46(4) e22

Published on-line:

May 25, 2022

DOI:

10.19186/BC_2022.034

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Alte concentrazioni di IL-6 nel liquido di dialisi peritoneale in un paziente affetto da peritonite
High levels of IL-6 on peritoneal dialysate in a patient with peritonitis

AUTHORS

Giulia Canu1, Gaetano Alfano2, Simonetta Tagliavini1, Tommaso Trenti1, Manuela Varani1
1Dipartimento di Medicina di Laboratorio e Anatomia Patologica, AUSL-AOU Modena
2Unità di Nefrologia, Dialisi e Trapianti, AOU, Modena

ABSTRACT

High levels of IL-6 on peritoneal dialysate in a patient with peritonitis.

Icodextrin has been associated with sterile peritonitis in patients on peritoneal dialysis. This peritonitis causes a cloudy effluent and mild abdominal discomfort, both resolved after the discontinuation of icodextrin. We report here a case of icodextrin-associated peritonitis coupled with high level of interleukin-6 (IL-6) on peritoneal dialysate. After the rechallenge with icodextrin, the Interleukin -6 (IL-6) increase was 9.8 fold higher, while the increase of the leucocyte count was only 4.3 fold higher compared to baseline. The icodextrin discontinuation induced a decrease of IL-6 and leucocyte count to baseline values while the peritoneal dialysate became clear. In conclusion, IL-6 could be considered a sensitive biomarker for the diagnosis of icodextrin-associated peritonitis.

REFERENCES