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OPINIONI - Opinions

Volume:

Biochimica Clinica 2022; 46(3) 241-246

Pubblicato on-line:

July 13, 2022

DOI:

10.19186/BC_2022.048

Scarica in PDF:

Sistema POCT per la determinazione su sangue intero della troponina cardiaca I ad alta sensibilità: quale valore nel territorio?
POCT system for the determination of high sensitivity cardiac troponin I: the value in the territory

AUTORI

Lucio Marchioro1,2, Monica Maria Mion1, Martina Zaninotto1,2, Mario Plebani1,2
1 U.O.C. Medicina di Laboratorio, Azienda Ospedale – Università di Padova
2 QI.LAB.MED. Padova

ABSTRACT

POCT system for the determination of high sensitivity cardiac troponin I: the value in the territory

The Italian National Recovery and Resilience Plan (NRRP) provides resources for the activation for over a thousand Community Houses that will serve as permanent points of reference for the population with the aim to guarantee both the prevention activity and the  care of patients. These structures need to be provided with Information Technology  (essential for the implementation of telemedecine), an adequate multi-specialty instrumental equipment (radiology, clinical laboratory) and a multidisciplinary team of medical specialists, paediatricians, nurses and other health professionals. In this context, the clinical laboratory activity takes on a strategic role especially in the diagnosis of the acute miocardial damage (AMI) which is fundamentally based on the determination of Troponin I o T and no longer on instrumental investigations, such as ECG. High quality POCT devices are currently available on the market for the determination of Troponin I (and T) with high sensitivity methods characterized by adequate costs for the diagnostic efficacy they should guarantee. Recently, the POCT system QuidelTriage High Sensitivity Troponin I test has been evaluated  using 75 whole blood samples from patients. Overall, the outcome of the trial was satisfactory and corresponded to the quality and performance specifications recommended by AACC and IFCC for a method that should assure  an elevated level of diagnostic accuracy. The tested POCT device was effective in the management of patients with suspected AMI using either single cut-off value or 0/1 hour algorithm. This demonstrates the important contribution that POCT devices can offer for of early diagnosis and monitoring of chronic disease

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